早期学试验：为何存在如此众多的试验设计者？

所写：SCI天一读过

Abstract

The past 30 years he seen a considerable effort on the part of statisticians to improve the design and accuracy of early-phase oncology trials. Some of this effort has been rewarded via successful implementation in actual trials, yet it would be fair to say that among clinicians, there remains some reluctance to fully embrace more efficient model-based approaches. One reason for such reticence is the difficulty in understanding exactly what is being offered by more modern designs. Although it is generally accepted that these designs offer improvements over the old standard 3 + 3 design, a new question has then to be addressed: How should we decide among the new proposals which one is the best for our purpose? In this study, we recall 15 designs that are currently proposed and in use. We show that among these 15 designs, many are operationally identical. These 15 designs reduce to three broad classes of designs. This review helps summarize their properties and differences and highlights that certain designs require ad hoc modifications to ensure satisfactory performance.

在现在的 30 年中的，昆虫学家在改进早期学次测试的外观设计和精准性方面付出了相当大的努力。其中的一些努力在一些出乎意料试行的次测试中的给与了期望，但负责任地说，在医学医生中的，仍然有些人不愿实质上采用更加有效的基于模型的次测试外观设计方式。这种阻力的可能之一是较难精准地忽略更加现代的外观设计能够带来什么。尽管人们视之为这些外观设计相较于现在新标准的3+3外观设计其余部分，但有一个上关键问题必须给与却说：我们不应如何在有数上新议案中的选择出最适合于我们目地的？在这项研究中的，我们回顾了目前提出和使用的 15 种外观设计。我们显示了在这 15 种外观设计中的，许多在操作上是相同的。这 15 种外观设计能够被归纳为三大类外观设计。这篇综述有助于总结它们的特点和差异，并重点突出了某些外观设计需要一些临时的改动以确保其能够起着令人满意的效用。

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